Takuma Okamoto1, Ayumi Iwata  This email address is being protected from spambots. You need JavaScript enabled to view it.1,2, Hiroko Yamanaka1, Kako Ogane1, Tatsuhiro Mori  1, Akiko Honda3,4, Hirohisa Takano4,5, Tomoaki Okuda  This email address is being protected from spambots. You need JavaScript enabled to view it.1 

1 Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kanagawa 223-8522, Japan
2 Meteorological Research Institute, Japan Meteorological Agency, Ibaraki 305-0052, Japan
3 Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan
4 Graduate School of Global Environmental Studies, Kyoto University, Kyoto 615-8540, Japan
Institute for International Academic Research, Kyoto University of Advanced Science, Kyoto 615-8577, Japan


Received: June 30, 2023
Revised: October 11, 2023
Accepted: December 7, 2023

 Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.


Download Citation: ||https://doi.org/10.4209/aaqr.230156  


Cite this article:

Okamoto, T., Iwata, A., Yamanaka, H., Ogane, K., Mori, T., Honda, A., Takano, H., Okuda, T. (2024). Characteristic Fe and Cu Compounds in Particulate Matter from Subway Premises in Japan and their Potential Biological Effects. Aerosol Air Qual. Res. 24, 230156. https://doi.org/10.4209/aaqr.230156


HIGHLIGHTS

  • Subway premise was dominant by metal particles such as Fe and Cu components.
  • Fe and Cu in the subway were different compounds from the typical atmosphere.
  • Fe and Cu compounds induced different cell responses based on their chemical states.
  • Subway particles can lead unique contributions in their biological effects.
 

ABSTRACT


Suspended particulate matter (PM) in subway premises contain high concentrations of metal components and distinctive compounds owing to their unique emission processes. However, little is known regarding the detailed chemical states of airborne PM and their biological effects. Therefore, to demonstrate the unique chemical states of the PM collected from subway premises and outdoors, this study compared the chemical speciation of iron (Fe) and copper (Cu) components using X-ray absorption fine structure analysis. The potential biological effects of these chemical states on humans were also investigated in vitro by assessing cell damage and its pathways in cells after exposure to several compounds. Compared with a reference outdoor PM sample, Fe was enhanced by at least 10 times in subway PM and the concentrations of several metal components, including Cu, contained in railway bodies, rail, overhead wires, and tunnel walls, also increased. In these chemical speciations, the compounds derived from wear processes with relatively high-temperature oxidation (Fe3O4, γ-Fe2O3, and monovalent Cu compounds) were detected among the Fe and Cu components in subway PM. Our cell-based bioassay suggested that the contribution of the Fe component to cell damage can be enhanced by the predominance of Fe3O4 in subway PM. In contrast to typical bivalent Cu compounds in the atmosphere, monovalent Cu compounds, which are characteristically identified in subway PM, exacerbate cell damage via different cell death pathways. Our results indicate that the chemical states of the distinctive compounds in the PM of subway premises differ from those in the typical atmosphere, thus exerting different biological effects. These findings suggest that the detailed chemical speciation is an important factor in accurately understanding their PM toxicities.


Keywords: Particulate matter, Subway premises, Chemical speciation, Cytotoxicity, X-ray absorption fine structure




Share this article with your colleagues 

 

Subscribe to our Newsletter 

Aerosol and Air Quality Research has published over 2,000 peer-reviewed articles. Enter your email address to receive latest updates and research articles to your inbox every second week.

7.3
2022CiteScore
 
 
77st percentile
Powered by
Scopus
 
   SCImago Journal & Country Rank

2022 Impact Factor: 4.0
5-Year Impact Factor: 3.4

Call for Papers for the special issue on: "Carbonaceous Aerosols in the Atmosphere"

Aerosol and Air Quality Research partners with Publons

CLOCKSS system has permission to ingest, preserve, and serve this Archival Unit
CLOCKSS system has permission to ingest, preserve, and serve this Archival Unit

Aerosol and Air Quality Research (AAQR) is an independently-run non-profit journal that promotes submissions of high-quality research and strives to be one of the leading aerosol and air quality open-access journals in the world. We use cookies on this website to personalize content to improve your user experience and analyze our traffic. By using this site you agree to its use of cookies.