David H. Gonzalez  , Suzanne E. Paulson  This email address is being protected from spambots. You need JavaScript enabled to view it. 

University of California at Los Angeles, Department of Atmospheric and Oceanic Sciences, Los Angeles, CA 90405, USA


Received: January 23, 2022
Revised: April 16, 2022
Accepted: May 16, 2022

 Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.


Download Citation: ||https://doi.org/10.4209/aaqr.220037  

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Cite this article:

Gonzalez, D.H., Paulson, S.E. (2022). Quantification of Malondialdehyde in Atmospheric Aerosols: Application of the Thiobarbituric Acid Method. Aerosol Air Qual. Res. 22, 220037. https://doi.org/10.4209/aaqr.220037


HIGHLIGHTS

  • The thiobarbituric acid assay was applied to atmospheric aerosols.
  • Malondialdehyde was observed and quantified in urban and biomass burning aerosols.
  • Concentrations of malondialdehyde in ambient aerosols were moderate.
  • Interference was minimal both from diacids and other dialdehydes.
 

ABSTRACT 


Based on available toxicity data, malondialdehyde (MDA; O=CHCH2CH=O) has been designated as a potential human carcinogen. A handful of studies suggest that MDA forms in the gas and aerosol phase in the troposphere, potentially contributing to inhalation toxicity, yet it has never been quantified in ambient air. The thiobarbituric acid (TBA) acid assay for MDA has been used as a marker for reactive oxygen species (ROS), oxidative stress, and lipid peroxidation in biological samples for decades. Here we apply the TBA assay to estimate the amount of MDA in ambient fine particulate matter (PM2.5) for the first time, in samples containing biomass burning/urban aerosol from Fresno, CA, and urban aerosol from Los Angeles. We found 0.31–0.75 ng m–3 MDA in the particle phase, similar to the low end, but up to three orders of magnitude lower than the upper end of reported concentrations of the common C3 oxygenates methylglyoxal and malonic acid. Additionally, we investigated the response in the TBA assay to seven common small oxygenates, and found interference only from acrolein, but only when the acrolein was at millimolar concentrations, well above expected levels in aerosol extracts. In sum, this work suggests that MDA is present at moderate levels in biomass burning and urban aerosols; more may be in the gas phase.


Keywords: Carbonyl quantification, Biomass burning, Urban aerosol, Aerosol toxicity, Assay interference




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