Amja Manullang1, Yueh-Lun Lee2, Vincent Laiman1,3, Jer-Hwa Chang This email address is being protected from spambots. You need JavaScript enabled to view it.4,5, Hsiao-Chi Chuang This email address is being protected from spambots. You need JavaScript enabled to view it.4,6,7 1 International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
2 Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
3 Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
4 School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
5 Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
6 Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
7 Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Received:
January 17, 2022
Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.
Revised:
April 6, 2022
Accepted:
April 27, 2022
Download Citation:
||https://doi.org/10.4209/aaqr.220027
Manullang, A., Lee, Y.L., Laiman, V., Chang, J.H., Chuang, H.C. (2022). Associations between Ozone and Emphysema: A Systematic Review and Meta-analysis. Aerosol Air Qual. Res. 22, 220027. https://doi.org/10.4209/aaqr.220027
Cite this article:
Air pollution is widely viewed as a serious threat to human health and a contributor to deaths. Air pollution appears to be linked to the progression of emphysema, according to epidemiological data. The objective of this study was to examine associations between air pollution and the progression of emphysema using a meta-analysis. A meta-analysis was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) protocol. A systematic literature search was conducted using the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, Embase, PubMed, and Web of Science bibliographic databases. A random-effects model for the meta-analysis was implemented to summarize effect estimates of sufficiently comparable outcomes and pollutants (e.g.: particulate matter, nitrogen oxides and ozone), and the results were visualized in forest plots. We observed that a 1-ppb rise in O3 was associated with a 0.30 increase in the percent emphysema progression (95% CI: 0.02, 0.57, p < 0.05). In contrast, no significant association was found between PM2.5 or NO2 exposure and the percent change in emphysema. Increasing O3 concentrations may have an impact on and exacerbate human health conditions such as emphysema and respiratory diseases. Air quality and climate change should be concerns for future environmental policies and protection measures.HIGHLIGHTS
ABSTRACT
Keywords:
Air pollution, COPD, Emphysema, Meta-analysis, Ozone
