Nguyen Thanh Tung1,2, Hoang Ba Dung2, Tran Phan Chung Thuy3, Huynh Nguyen Xuan Thao4, Hsiao-Chi Chuang This email address is being protected from spambots. You need JavaScript enabled to view it.5,6,7

1 International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
2 Otorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam
3 Otorhinolaryngology Department, Faculty of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam
4 Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
5 School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
6 Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
7 Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Received: July 2, 2020
Revised: October 1, 2020
Accepted: November 11, 2020

 Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

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Cite this article:

Tung, N.T., Dung, H.B., Thuy, T.P.C., Thao, H.N.X., Chuang, H.C. (2021). Air Pollution and Respiratory Permeability in Obstructive Sleep Apnea - A Review. Aerosol Air Qual. Res. 21, 200369.


  • Increased prevalence of OSA.
  • Numerous risk factors for OSA.
  • Permeability of body fluids and OSA are highly correlated.
  • PM may cause OSA through oxidative stress and inflammation.
  • Air pollution increases permeability in the airway by reducing tight junction proteins.


Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of nocturnal upper airway obstruction during sleep, which can seriously affect sleep quality and cause sleepiness during the daytime. Known risk factors for OSA are numerous, including obesity, age, gender, craniofacial anatomy, smoking, alcohol consumption, and genetic inheritance. Recently, air pollution was linked to an increased risk of OSA severity. Alterations in permeability are considered to be an important factor in the development of OSA; however, the role of air pollution remains unclear. This review article explored the role of air pollution and airway permeability in the pathogenesis of OSA.

Keywords: Apnea Hypopnea Index, Nocturnal fluid shift, Obstructive sleep apnea, Particulate matter, Permeability

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