Special Session on Pulmonary and Neurological Health Impacts from Airborne Particulate Matter (II)

Yi-Hsueh Liao1,2,4,5,6, Wei-Liang Chen3,6, Chung-Ching Wang3,6, Ching-Huang Lai This email address is being protected from spambots. You need JavaScript enabled to view it.4

1 Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
2 Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei 11490, Taiwan
3 Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei 11490, Taiwan
4 School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
5 School of Medicine, Taipei Medical University, Taipei 11031, Taiwan
6 School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan


 

Received: April 19, 2020
Revised: June 20, 2020
Accepted: July 2, 2020

 Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.


Download Citation: ||https://doi.org/10.4209/aaqr.2020.04.0156  

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Cite this article:

Liao, Y.H., Chen, W.L., Wang, C.C. and Lai, C.H. (2020). Associations between Personal Exposure to Metals in Fine Particulate Matter and Autonomic Nervous System Dysfunction among Healthy Adults. Aerosol Air Qual. Res. 20: 1842–1849. https://doi.org/10.4209/aaqr.2020.04.0156


HIGHLIGHTS

  • Exposure to metals in PM2.5 was associated with ANS dysfunction.
  • Significant changes in SDNN, r-MSSD levels were related to iron in PM2.5.
  • The SDNN levels were significantly positively related to gallium in PM2.5.
 

ABSTRACT


The impact of airborne particulate matter and its metal components on autonomic nervous system (ANS) dysfunction in healthy subjects remains unclear. The aim of this study was to examine the effects of personal exposure to airborne particulate matter on the ANS in young, healthy adults. This longitudinal study recruited 82 adults aged 20 to 35 years from districts A and B. District A had lower ambient PM2.5 levels than district B. Personal exposure to fine particulate matter and metals in PM2.5 was collected every two months. The heart rate variability (HRV) indices of each participant were measured three times. The relationship among the PM2.5 concentration, metals in PM2.5 and HRV level was investigated by a generalized estimating equation with an autoregression of order 1. The average age of the participants was 26.4 ± 3.6 years in district A and 21.9 ± 1.5 years in district B (< 0.001). After adjusting for covariables, significant changes in Log10 standard deviation of normal to normal (SDNN) intervals and Log10 square root of the mean of the sum of the squares of differences (r-MSSDs) were related to unit changes in Log10 iron in PM2.5 (β = –0.033, 95% CI = –0.060 to –0.0056, p < 0.05 and β = –0.041, 95% CI = –0.075 to –0.0076, < 0.05, respectively). The Log10 SDNN levels were significantly positively related to Log10 gallium in PM2.5 (β = 0.054, 95% CI = 0.0064 to 0.10, < 0.05). Exposure to heavy metals in airborne particulate matter was associated with ANS dysfunction.


Keywords: Particulate matter; Metals; Autonomic nervous system.



REFERENCES


  1. Adar, S.D., Gold, D.R., Coull, B.A., Schwartz, J., Stone, P.H. and Suh, H. (2007). Focused exposures to airborne traffic particles and heart rate variability in the elderly. Epidemiology 18: 95–103. [Publisher Site]

  2. Block, M.L. and Calderon-Garciduenas, L. (2009). Air pollution: Mechanisms of neuroinflammation and cns disease. Trends Neurosci. 32: 506–516. [Publisher Site]

  3. Brook, R.D., Rajagopalan, S., Pope, C.A., 3rd, Brook, J.R., Bhatnagar, A., Diez-Roux, A.V., Holguin, F., Hong, Y., Luepker, R.V., Mittleman, M.A., Peters, A., Siscovick, D., Smith, S.C., Jr., Whitsel, L. and Kaufman, J.D. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the american heart association. Circulation 121: 2331–2378. [Publisher Site]

  4. Cavallari, J.M., Eisen, E.A., Fang, S.C., Schwartz, J., Hauser, R., Herrick, R.F. and Christiani, D.C. (2008). PM2.5 metal exposures and nocturnal heart rate variability: A panel study of boilermaker construction workers. Environ. Health 7: 36. [Publisher Site]

  5. Chang, C.C., Yuan, C.S., Li, T.C., Su, Y.L., Tong, C. and Wu, S.P. (2018). Chemical characteristics, source apportionment, and regional transport of marine fine particles toward offshore islands near the coastline of northwestern Taiwan Strait. Environ. Sci. Pollut. Res. Int. 25: 32332–32345. [Publisher Site]

  6. Chen, J.C., Stone, P.H., Verrier, R.L., Nearing, B.D., MacCallum, G., Kim, J.Y., Herrick, R.F., You, J., Zhou, H. and Christiani, D.C. (2006). Personal coronary risk profiles modify autonomic nervous system responses to air pollution. J. Occup. Environ. Med. 48: 1133–1142. [Publisher Site]

  7. Chen, Y.C., Hsu, C.Y., Lin, S.L., Chang-Chien, G.P., Chen, M.J., Fang, G.C. and Chiang, H.C. (2015). Characteristics of concentrations and metal compositions for PM2.5 and PM2.5–10 in yunlin county, taiwan during air quality deterioration. Aerosol Air Qual. Res. 15: 2571–2583. [Publisher Site]

  8. Chuang, H.C., Hsueh, T.W., Chang, C.C., Hwang, J.S., Chuang, K.J., Yan, Y.H. and Cheng, T.J. (2013). Nickel-regulated heart rate variability: The roles of oxidative stress and inflammation. Toxicol. Appl. Pharmacol. 266: 298–306. [Publisher Site]

  9. Cowell, W.J., Brunst, K.J., Malin, A.J., Coull, B.A., Gennings, C., Kloog, I., Lipton, L., Wright, R.O., Enlow, M.B. and Wright, R.J. (2019). Prenatal exposure to PM2.5 and cardiac vagal tone during infancy: Findings from a multiethnic birth cohort. Environ. Health Perspect. 127: 107007.[Publisher Site]

  10. Electrophysiology - Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996). Heart rate variability. Circulation 93: 1043–1065. [Publisher Site]

  11. Fang, G.C., Chang, C.N., Chu, C.C., Wu, Y.S., Fu, P.P., Yang, I.L. and Chen, M.H. (2003). Characterization of particulate, metallic elements of TSP, PM(2.5) and PM(2.5-10) aerosols at a farm sampling site in Taiwan, Taichung. Sci. Total Environ. 308: 157–166. [Publisher Site]

  12. Fang, S.C., Wu, Y.L. and Tsai, P.S. (2019). Heart rate variability and risk of all-cause death and cardiovascular events in patients with cardiovascular disease: A meta-analysis of cohort studies. Biol. Res. Nurs. 22: 45–56. [Publisher Site]

  13. Fiordelisi, A., Piscitelli, P., Trimarco, B., Coscioni, E., Iaccarino, G. and Sorriento, D. (2017). The mechanisms of air pollution and particulate matter in cardiovascular diseases. Heart Fail. Rev. 22: 337–347. [Publisher Site]

  14. Geiger, A. and Cooper, J. (2010) Overview of airborne metals regulations, exposure limits, health effects, and contemporary research. Environmental Protection Agency, Portland, pp. 1-56. [PDF Link]

  15. Jia, X., Yang, X., Hu, D., Dong, W., Yang, F., Liu, Q., Li, H., Pan, L., Shan, J., Niu, W., Wu, S., Deng, F. and Guo, X. (2018). Short-term effects of particulate matter in metro cabin on heart rate variability in young healthy adults: Impacts of particle size and source. Environ. Res. 167: 292–298. [Publisher Site]

  16. Kim, S.Y., Kim, J.K., Park, S.H., Kim, B.G., Jang, A.S., Oh, S.H., Lee, J.H., Suh, M.W. and Park, M.K. (2018). Effects of inhaled particulate matter on the central nervous system in mice. Neurotoxicology 67: 169–177. [Publisher Site]

  17. Krishnan, R.M., Sullivan, J.H., Carlsten, C., Wilkerson, H.W., Beyer, R.P., Bammler, T., Farin, F., Peretz, A. and Kaufman, J.D. (2013). A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Part. Fibre Toxicol. 10: 7. [Publisher Site]

  18. Li, T.C., Yuan, C.S., Huang, H.C., Lee, C.L., Wu, S.P. and Tong, C. (2016). Inter-comparison of seasonal variation, chemical characteristics, and source identification of atmospheric fine particles on both sides of the Taiwan Strait. Sci. Rep. 6: 22956. [Publisher Site]

  19. Lin, K.P., Lin, G.H. and Chang, Y.H. (2005). Comparison of heart rate variability measured by ECG in different signal lengths. J. Med. Biol. Eng. 25: 67–71. [Website Link]

  20. Madsen, C., Rosland, P., Hoff, D.A., Nystad, W., Nafstad, P. and Naess, O.E. (2012). The short-term effect of 24-h average and peak air pollution on mortality in Oslo, Norway. Eur. J. Epidemiol. 27: 717–727. [Publisher Site]

  21. Magari, S.R., Schwartz, J., Williams, P.L., Hauser, R., Smith, T.J. and Christiani, D.C. (2002). The association of particulate air metal concentrations with heart rate variability. Environ. Health Perspect. 110: 875–880. [Publisher Site]

  22. Mirowsky, J.E., Peltier, R.E., Lippmann, M., Thurston, G., Chen, L.C., Neas, L., Diaz-Sanchez, D., Laumbach, R., Carter, J.D. and Gordon, T. (2015). Repeated measures of inflammation, blood pressure, and heart rate variability associated with traffic exposures in healthy adults. Environ. Health 14: 66. [Publisher Site]

  23. Moritani, T., Kimura, T., Hamada, T. and Nagai, N. (2005). Electrophysiology and kinesiology for health and disease. J. Electromyogr. Kinesiol. 15: 240–255. [Publisher Site]

  24. Riediker, M., Cascio, W.E., Griggs, T.R., Herbst, M.C., Bromberg, P.A., Neas, L., Williams, R.W. and Devlin, R.B. (2004). Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am. J. Respir. Crit. Care Med. 169: 934–940. [Publisher Site]

  25. Schwela, D. (2000). Air pollution and health in urban areas. Rev. Environ. Health 15: 13–42. [Publisher Site]

  26. Shaffer, F. and Ginsberg, J.P. (2017). An overview of heart rate variability metrics and norms. Front. Public Health 5: 258–258. [Publisher Site]

  27. Shutt, R.H., Kauri, L.M., Weichenthal, S., Kumarathasan, P., Vincent, R., Thomson, E.M., Liu, L., Mahmud, M., Cakmak, S. and Dales, R. (2017). Exposure to air pollution near a steel plant is associated with reduced heart rate variability: A randomised crossover study. Environ. Health 16: 4. [Publisher Site]

  28. Wang, C.F., Jeng, S.L. and Shieh, F.J. (1997). Determination of arsenic in airborne particulate matter by inductively coupled plasma mass spectrometry J. Anal. At. Spectrom. 12: 61–67. [Publisher Site]

  29. Wang, Y., Xiong, L. and Tang, M. (2017). Toxicity of inhaled particulate matter on the central nervous system: Neuroinflammation, neuropsychological effects and neurodegenerative disease. J. Appl. Toxicol. 37: 644–667. [Publisher Site]

  30. White, S.J.O. and Shine, J.P. (2016). Exposure potential and health impacts of indium and gallium, metals critical to emerging electronics and energy technologies. Curr. Environ. Health Rep. 3: 459–467. [Publisher Site]

  31. Wu, Li, Y.R., Kuo, I.C., Hsu, S.C., Lin, L.Y. and Su, T.C. (2012). Investigating the association of cardiovascular effects with personal exposure to particle components and sources. Sci. Total Environ. 431: 176–182. [Publisher Site]

  32. Wu, S., Deng, F., Niu, J., Huang, Q., Liu, Y. and Guo, X. (2010). Association of heart rate variability in taxi drivers with marked changes in particulate air pollution in Beijing in 2008. Environ. Health Perspect. 118: 87–91. [Publisher Site]

  33. Zeger, S.L. and Liang, K.Y. (1986). Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42: 121–130.

  34. Zhang, J.J. and Samet, J.M. (2015). Chinese haze versus western smog: Lessons learned. J. Thorac. Dis. 7: 3–13. [Publisher Site]

Aerosol Air Qual. Res. 20 :1842 -1849 . https://doi.org/10.4209/aaqr.2020.04.0156  

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