Nur Hazirah Hisamuddin, Juliana Jalaludin This email address is being protected from spambots. You need JavaScript enabled to view it., Aina Nadirah Yusof

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia Serdang, Selangor, Malaysia


Received: April 22, 2020
Revised: September 20, 2020
Accepted: October 4, 2020

 Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.


Download Citation: ||https://doi.org/10.4209/aaqr.2020.03.0114  

  • Download: PDF


Cite this article:

Hisamuddin, N.H., Jalaludin, J. and Yusof, A.N. (2020). Genotoxic Effects of Exposure to Urban Traffic Related Air Pollutants on Children in Klang Valley, Malaysia. Aerosol Air Qual. Res. https://doi.org/10.4209/aaqr.2020.03.0114


HIGHLIGHTS

  • Children in high traffic area have higher MN frequency than low traffic area.
  • TRAPs were significantly associated with phlegm symptoms and MN frequency.
  • NO2 and CO have significantly influenced the MN frequency in children.
  • TRAPs exposure increased risk of respiratory symptoms and MN formation in children.
 

ABSTRACT


Traffic-related air pollutants (TRAPs) are currently increasing due to the increment of vehicle numbers in Malaysia. The emission of pollutants from these vehicles have genotoxic properties that can potentially induce genetic damage in human. In this study, micronuclei assay is used to determine the potential genotoxic exposure by assessing the presence of micronuclei frequency (MN) in buccal cells. The specific objective of this study is to determine the association between TRAPs and frequency of MN among school children in Klang Valley. A comparative cross-sectional study was conducted among primary school children (9-11 years old) in high-density traffic area (n=94, Kuala Lumpur) and low-density traffic area (n=94, Hulu Langat). A questionnaire was distributed to the parents to obtain respiratory symptoms information. Buccal cells were analyzed to determine the frequency of micronuclei. Air quality assessment was carried out in a total of 6 schools (consisted of exposed and comparative groups) by using TSI DustTrak DRX Aerosol Monitor 8534 for measurement of PM2.5 and PM10, LaMotte’s Model BD Air Sampling Pump for measurement of Nitrogen dioxide (NO2) and Sulphur dioxide (SO2), ppbRAE 3000 for total Volatile Organic Compound (TVOC) and TSI Q-TRAK 7565 for measurement of Carbon dioxide (CO2) and Carbon monoxide (CO). The concentrations of PM10, PM2.5, NO2, SO2, TVOC and CO at exposed schools were significantly higher (p<0.005). compared to those in comparative schools. All pollutants were significantly associated (p<0.001) with respiratory symptom phlegm and MN frequency. Additionally, the MN frequency in the exposed group was significantly higher (p<0.001) than in the comparative group. All in all, this study demonstrated that air pollutants, especially NO2 and CO, have significantly influenced the MN frequency among children in primary schools. This study suggested that exposure to TRAPs among Malaysian school children has increased the risk for respiratory complications with the formation of MN.


Keywords: TRAPs; Urban traffic pollutants, Genotoxicity; Micronuclei frequency; Children.




Don't forget to share this article 

 

Subscribe to our Newsletter 

Aerosol and Air Quality Research has published over 2,000 peer-reviewed articles. Enter your email address to receive latest updates and research articles to your inbox every second week.