A Combined Computational and Experimental Study on Nanoparticle Transport and Partitioning in the Human Trachea and Upper Bronchial Airways

Jiawei Ma; Wei-Chung Su; Yi Chen; Yidan Shang; Jingliang Dong; Jiyuan Tu; Lin Tian

doi:10.4209/aaqr.2020.01.0015

A Combined Computational and Experimental Study on Nanoparticle Transport and Partitioning in the Human Trachea and Upper Bronchial Airways

Air Pollution and Health Effects Nanoparticles

Jiawei Ma¹, Wei-Chung Su This email address is being protected from spambots. You need JavaScript enabled to view it.², Yi Chen², Yidan Shang¹, Jingliang Dong¹, Jiyuan Tu¹, Lin Tian This email address is being protected from spambots. You need JavaScript enabled to view it.¹

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¹School of Engineering – Mechanical and Automotive, RMIT University, Bundoora, VIC, Australia
²School of Public Health, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas - Health Science Center at Houston, TX, USA

Received: January 12, 2020
Revised: April 10, 2020
Accepted: June 16, 2020

Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Download Citation: ||https://doi.org/10.4209/aaqr.2020.01.0015

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Cite this article:

Ma, J., Su, W.C., Chen, Y., Shang, Y., Dong, J., Tu, J. and Tian, L. (2020). A Combined Computational and Experimental Study on Nanoparticle Transport and Partitioning in the Human Trachea and Upper Bronchial Airways. Aerosol Air Qual. Res. https://doi.org/10.4209/aaqr.2020.01.0015

HIGHLIGHTS

Nanoparticle transport and partition to airway morphology was investigated.
Small-scale wall shear fluctuation is only seen in the anatomical model.
Nanoparticle mixing in the anatomical model was significantly more efficient.
Flow and particle partition in lung lobes were not necessary in proportion.
Simulated flow partition among 5 lobar airways was dependent on boundary condition.

ABSTRACT

In the past few decades, the transport and deposition of aerosol in the human respiratory tract has been a crucial area of research, resulting in the identification of the toxicity pathways of inhaled pollutants and facilitating the design of efficient drug delivery systems for targeted treatment. Owing to the complexity of the tracheobronchial tree, experimental studies in vivo/in vitro have been extremely limited; hence, detailed data on the airflow and particle dynamics have been obtained predominantly through computational investigations. With rapid advances in medical imaging and computational capacities, sophisticated human tracheobronchial trees that include the 6^th, 7^th or 15^th generation have been increasingly described in the literature. However, continued progress in anatomical reconstruction and mathematical idealized modeling, the two most frequently employed approaches to airway modeling, requires a detailed fundamental analysis on the morphology-induced sensitivity of particle-flow partitioning, and particle deposition in the airways. This study combined numerical and experimental investigations on the transport, deposition and partitioning of nanoparticles in the upper tracheobronchial airways. An anatomically realistic airway was reconstructed via CT scans, and a simplified numerical model was developed that incorporated physical irregularities in the trachea and assessed new boundary conditions to simulate air partitioning in the lobar bronchi, and flow and particle dynamics. An experiment measuring the penetration and deposition of sodium chloride (NaCl) nanoparticles in the anatomical and idealized airway models was conducted in parallel, and the results were compared with the computational predictions.

Keywords: Airway morphology; Nanoparticle transport; Deposition and partitioning; Tracheobronchial tree; Computational modeling; Experimental measurement.

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