Source Specific Cyto- and Genotoxicity of Atmospheric Aerosol Samples

A´gnes Filep; Luka  Drinovec; Andrea Pala´gyi; La´szlo´ Manczinger; Csaba Va´gvo¨lgyi; Zolta´n Bozo´ki; Regina Hitzenberger; Ga´bor Szabo´

doi:10.4209/aaqr.2015.03.0131

Source Specific Cyto- and Genotoxicity of Atmospheric Aerosol Samples

Physical and Chemical Characteristics of Aerosols

Ágnes Filep ¹^,2, Luka Drinovec³, Andrea Palágyi⁴, László Manczinger⁴, Csaba Vágvölgyi⁴, Zoltán Bozóki¹^,2, Regina Hitzenberger⁵, Gábor Szabó¹^,2

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¹Department of Optics and Quantum Electronics, University of Szeged, Szeged, Hungary
²MTA-SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary
³Aerosol d.o.o., Ljubljana, Slovenia
⁴Department of Microbiology, FSI, University of Szeged, Szeged, Hungary
⁵Faculty of Physics, University of Vienna, 1090 Vienna, Austria

Received: March 1, 2015
Revised: August 7, 2015
Accepted: September 15, 2015
Download Citation: ||https://doi.org/10.4209/aaqr.2015.03.0131

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Cite this article:
Filep, A., Drinovec, L., Palágyi, A., Manczinger, L., Vágvölgyi, C., Bozóki, Z., Hitzenberger, R. and Szabó, G. (2015). Source Specific Cyto- and Genotoxicity of Atmospheric Aerosol Samples. Aerosol Air Qual. Res. 15: 2325-2331. https://doi.org/10.4209/aaqr.2015.03.0131

HIGHLIGHTS

We determined cyto- and genotoxicity of PM_2.5 samples.
We performed on-line source apportionment based on Aethalometer measurement.
We measured OC/EC and heavy metal content of PM_2.5 samples.
We revealed connection between emission source and cyto- and genotoxicity.

ABSTRACT

Atmospheric aerosol samples were studied during wintry conditions at three Hungarian locations (rural background, urban background, traffic site). Ratio of biomass burning and fossil fuel related aerosol were highly different at the sampling points. Cyto- and genotoxicity of the samples were measured by using Pseudomonas putida growth inhibition test and Ames test, respectively. Dominant particle emission sources were apportioned through tracer heavy metal content measurement, optically and thermo-optically methods. According to the results, both ecotoxicity parameters are strongly emission source dependent; the higher the ratio of the biomass burning related carbonaceous aerosol the higher the cytotoxicity and the higher the ratio of the fossil fuel related carbonaceous aerosol the higher the genotoxicity. Cytotoxicity showed positive correlation with carbonaceous aerosol related to biomass burning (R² = 0.74) and negative with lead content of the samples (R² = –0.56). Genotoxicity showed positive correlation with carbonaceous aerosol related to traffic (R² = 0.42) and cadmium content of the samples (R² = 0.74). At the same time, it showed negative correlation with organic/elemental carbon ratio of the samples (R² = –0.43).

Keywords: PM2.5; Source apportionment; Toxicology