Bing-Yu Chen1, Chi-Hsien Chen1, Pau-Chung Chen2, Gen-Shuh Wang3, Yue Leon Guo 1

  • 1 Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
  • 2 Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan
  • 3 Institute of Environmental Health, National Taiwan University, Taipei, Taiwan

Received: November 1, 2012
Revised: February 27, 2013
Accepted: February 27, 2013
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Cite this article:
Chen, B.Y., Chen, C.H., Chen, P.C., Wang, G.S. and Guo, Y.L. (2013). Air Pollution, Allergic Co-morbidity, and Emergency Department Visit for Pediatric Asthma in Taiwan. Aerosol Air Qual. Res. 13: 1847-1852.



Background: Alterations in allergic susceptibility are a central feature of several chronic respiratory diseases. This study was conducted to determine whether variation in individual allergic susceptibility alters the air pollution effects on attacks of pediatric asthma.

Methods: Daily records of personal asthma emergency department visits among children in school-age and ambient air pollutant concentration were obtained from 2000 to 2008 in Taipei basin, Taiwan. Subjects who had ever had a clinical visit in the departments of otolaryngology and pediatrics or a visit to the emergency department due to allergic rhinitis before their first asthma-related emergency department visit were defined as having allergic rhinitis co-morbidities. A time-stratified approach for the case-crossover technique and a conditional logistic regression were used to examine whether allergic co-morbidity modified air pollution-induced asthma attacks.

Results: Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) was found to be associated with asthma-related emergency department visits on the day of exposure among children with allergic rhinitis co-morbidity (2nd quartile OR = 1.19; 3rd quartile OR = 1.37; 4th quartile OR = 1.38). High ozone levels were associated with emergency room visits for asthma on a 1-day lag assumption among children with allergic rhinitis co-morbidity (4th quartile OR = 1.38).

Conclusion: The negative effects of air pollution were observed for subjects who had an allergic co-morbidity. The variation in allergic co-morbidity was associated with differences in susceptibility to the adverse effects of air pollutants on respiratory disease.

Keywords: Air pollution; Asthma; Allergic rhinitis; Co-morbidity

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