Air Pollution, Allergic Co-morbidity, and Emergency Department Visit for Pediatric Asthma in Taiwan

Bing-Yu Chen; Chi-Hsien Chen; Pau-Chung Chen; Gen-Shuh Wang; Yue Leon Guo

doi:10.4209/aaqr.2012.11.0299

Air Pollution, Allergic Co-morbidity, and Emergency Department Visit for Pediatric Asthma in Taiwan

Bing-Yu Chen¹, Chi-Hsien Chen¹, Pau-Chung Chen², Gen-Shuh Wang³, Yue Leon Guo ¹

¹Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
²Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan
³Institute of Environmental Health, National Taiwan University, Taipei, Taiwan

Received: November 1, 2012
Revised: February 27, 2013
Accepted: February 27, 2013
Download Citation: ||https://doi.org/10.4209/aaqr.2012.11.0299

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Cite this article:
Chen, B.Y., Chen, C.H., Chen, P.C., Wang, G.S. and Guo, Y.L. (2013). Air Pollution, Allergic Co-morbidity, and Emergency Department Visit for Pediatric Asthma in Taiwan. Aerosol Air Qual. Res. 13: 1847-1852. https://doi.org/10.4209/aaqr.2012.11.0299

ABSTRACT

Background: Alterations in allergic susceptibility are a central feature of several chronic respiratory diseases. This study was conducted to determine whether variation in individual allergic susceptibility alters the air pollution effects on attacks of pediatric asthma.

Methods: Daily records of personal asthma emergency department visits among children in school-age and ambient air pollutant concentration were obtained from 2000 to 2008 in Taipei basin, Taiwan. Subjects who had ever had a clinical visit in the departments of otolaryngology and pediatrics or a visit to the emergency department due to allergic rhinitis before their first asthma-related emergency department visit were defined as having allergic rhinitis co-morbidities. A time-stratified approach for the case-crossover technique and a conditional logistic regression were used to examine whether allergic co-morbidity modified air pollution-induced asthma attacks.

Results: Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM_2.5) was found to be associated with asthma-related emergency department visits on the day of exposure among children with allergic rhinitis co-morbidity (2^nd quartile OR = 1.19; 3^rd quartile OR = 1.37; 4^th quartile OR = 1.38). High ozone levels were associated with emergency room visits for asthma on a 1-day lag assumption among children with allergic rhinitis co-morbidity (4^th quartile OR = 1.38).

Conclusion: The negative effects of air pollution were observed for subjects who had an allergic co-morbidity. The variation in allergic co-morbidity was associated with differences in susceptibility to the adverse effects of air pollutants on respiratory disease.

Keywords: Air pollution; Asthma; Allergic rhinitis; Co-morbidity