Ching-Huang Lai 1, Saou-Hsing Liou1,2, Jouni J.K. Jaakkola3, Han-Bin Huang4, Ting-Yao Su4, Paul T. Strickland5

  • 1 Department of Public Health, National Defence Medical Center, Taipei 114, Taiwan
  • 2 Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli County 350, Taiwan
  • 3 Center for Environmental and Respiratory Health Research, Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland
  • 4 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
  • 5 Department of Environment Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA

Received: January 31, 2012
Revised: April 29, 2012
Accepted: April 29, 2012
Download Citation: ||  

  • Download: PDF

Cite this article:
Lai, C.H., Liou, S.H., Jaakkola, J.J., Huang, H.B., Su, T.Y. and Strickland, P.T. (2012). Exposure to Polycyclic Aromatic Hydrocarbons Associated with Traffic Exhaust: The Increase of Lipid Peroxidation and Reduction of Antioxidant Capacity. Aerosol Air Qual. Res. 12: 941-950.



This study was carried out to examine the association between exposure to polycyclic aromatic hydrocarbon with traffic exhaust and biomarkers of lipid peroxidation and antioxidant levels among highway toll station workers. We conducted a cross-sectional study of 47 female highway toll station workers exposed to traffic exhausts and 27 female classroom trainees as a reference group. Exposure assessment was based on a biomarker of polycyclic aromatic hydrocarbon exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary isoprostane was assayed as a biomarker of lipid peroxidation, and plasma antioxidative capacity of lipid-soluble substances (ACL) and water-soluble substances (ACW) was measured. The median concentration of urinary isoprostane was higher among the exposed non-smokers (4.63 ng/mL) compared with the reference non-smokers (3.52 ng/mL, difference: 0.91, 95% CI –0.15 to 1.98) (Wilcoxon rank-sum test: p = 0.04). The median concentration of ACW among non-smoking exposed subjects (37.9 μg/mL Trolox equivalent) was lower than that of the reference non-smokers (86.3 μg/mL). Adjusting for confounding effects by linear regression, a change in log(isoprostane) concentration was significantly related to a unit change in log(1-OHPG) (regression coefficient [ß], β = 0.14, 95% CI 0.07 to 0.21). Exposure to polycyclic aromatic hydrocarbon is associated with increased lipid peroxidation and reduced antioxidative capacity in toll station workers.

Keywords: Air pollution; 1-hydroxypyrene-glucuronide; Isoprostane; Antioxidant capacity

Share this article with your colleagues 


Subscribe to our Newsletter 

Aerosol and Air Quality Research has published over 2,000 peer-reviewed articles. Enter your email address to receive latest updates and research articles to your inbox every second week.

77st percentile
Powered by
   SCImago Journal & Country Rank

2022 Impact Factor: 4.0
5-Year Impact Factor: 3.4

Aerosol and Air Quality Research partners with Publons

CLOCKSS system has permission to ingest, preserve, and serve this Archival Unit
CLOCKSS system has permission to ingest, preserve, and serve this Archival Unit

Aerosol and Air Quality Research (AAQR) is an independently-run non-profit journal that promotes submissions of high-quality research and strives to be one of the leading aerosol and air quality open-access journals in the world. We use cookies on this website to personalize content to improve your user experience and analyze our traffic. By using this site you agree to its use of cookies.