A quadrotor drone was equipped with an active solid phase microextraction (SPME) sampling device, called a needle trap sampler (NTS), to extract airborne volatile organic compounds (VOCs). The NTS, which has a 22 gauge stainless steel needle that is manually packed with 60–80 mesh divinylbenzene (DVB) adsorbent particles, was attached to a telescoping shaft to extend the sampling distance outside the strong downward stream that flows across the propellers of a hovering drone. The optimal location of the end of the NTS inlet to extract VOCs in the air was below the head of the drone, as determined using SoildWorks, which is a flow simulation software. The feasibility of using a telescoping SPME sampling device on a quadrotor drone to collect toluene, ethylbenzene and p-xylene matrix vapor using a pilot VOC exhaustion system, was confirmed. The mobile sampling drone, with an NTS on its telescoping shaft, is recommended for use in sampling polluted air that is emitted from industrial factories.