There is little information regarding the aerosol exposure produced by medical nebulizers and the factors affecting the exposure, especially for treatments performed in a patient home environment. Home healthcare workers (HHWs) is a rapidly growing work population often exposed to aerosol hazards. Here, we designed a simulated environment to measure the inhalation aerosol exposure of a HHW administering pressure-nebulized medications. We determined the relative contributions of different factors on the aerosol reduction in the exposure chamber simulating a patient’s bedroom, including room air exchange rate, proximity to the patient, and the patient breathing rate. Additionally, the performance of respiratory protective devices worn by a HHW, a surgical mask and N95 filtering facepiece respirator (FFR), was evaluated with NaCl as a well-established surrogate. The particle concentration in the breathing zone of an unprotected worker ranged from 7,118 to 284,600 cm-3. The proximity to the aerosol source was found to be a factor influencing the aerosol concentration, but the distance effect diminished when it increased beyond 24 inches. For an unprotected HHW, ventilation was the most effective way to reduce the occupational exposure to nebulizer-produced medical aerosols. An increase in air exchange rate from 0 to 5 h-1 significantly reduced the exposure; however, further increase (to 17 h-1) provided only a minor decrease in the particle concentration. Thus, there is no evidence that patient homes need an extremely efficient ventilation to mitigate the HHW’s exposure to the nebulizer-produced medications. Increase in patient breathing flow rate reduced the inhalation aerosol exposure; however, this factor cannot be controlled, which weakens its practical viability. Wearing respiratory protection devices was found to be the most efficient way to reduce aerosol exposure (within the set of the tested variables). As expected, an N95 FFR with a proper seal was about 20-fold more efficient than a surgical mask.