Non-polybrominated diphenyl ether (non-PBDE) halogenated fire retardants (HFRs) such as new or novel brominated fire retardants (NBFRs) and dechlorance plus (DPs) have been widely spreading in the environment and are recognized as emerging persistent organic pollutants (POPs) in the recent years, mainly due to the continuous increase of its global demand specially after the worldwide restrictions on PBDE use. Polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) are the unintentional byproducts of PBDE commercial formulations in the indoor environment. Although HFRs including NBFRs, DPs, and PBDD/Fs are ubiquitous in the indoor environment due to the large-volume release on the surfaces of consumer products, only a few in vitro and in vivo studies have addressed their toxic effects. In this review article, global data of NBFRs, including decabromodiphenyl ethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (BEH-TEBP), and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), DPs, including syn-DP and anti-DP, and PBDD/Fs in indoor aerosol and dust are summarized from recent literature. Based on the gathered data, indoor dust is a major sink for indoor contamination and is of great concern due to the fact that dust ingestion is one of the primary routes for human exposure to these chemicals. Lastly, toxic effects of NBFRs, DPs, and PBDD/Fs based from in vitro and in vivo studies are summarized and discussed based on the current published reports. However, there is still a lack of sufficient toxicity data to assess their risks. Future works are encouraged to focus on indoor PM2.5-bound HFR levels to further evaluate their toxic effects to human health.