HEPA filter media have been used in many fields to maintain a super clean indoor air environment for various purposes. Novel PTFE HEPA media have attracted growing research interest because of their much lower initial resistance. Solid KCl particles loading experiments were carried out to examine the dust loading performance of PTFE media and their comparison with that of glass fiber media. The experimental results provided insights into the surface deposit mode of particles captured by PTFE media. A new resistance growth coefficient, k2 was defined to reflect both the instantaneous growth rate of dynamic pressure drop and the dust loading stage of HEPA media. In addition, energy consumption evaluation method for HEPA media was developed by calculating the average pressure drop during laboratory dust loading experiments. It was shown by using the method that overall speaking, PTFE HEPA media are more energy efficient compared to glass fiber except for the circumstances of heavy load or long serviced period.