To study the formation process of secondary organic aerosols (SOA) in a vehicle exhaust plume near the exhaust gas discharge outlet, a new multipoint sampling system was established. The system has five sampling heads and includes a particulate matter multi-channel film sampling system, a CO2/CO analyzer system, a volatile organic compound (VOC) sampling system, a particulate matter real-time analyzer system, and sensor interfaces. The vehicle exhaust near the exhaust nozzle can be sampled at multiple locations simultaneously using the new multipoint sampling system. Additionally, the system can be used to measure and analyze variations in the fine particulate matter, including the carbonaceous and ionic components, and organic compounds in the plume near the exhaust nozzle. This paper introduces the construction and application of the multipoint sampling system. The motor vehicle exhaust multipoint sampling system is reliable and can accurately capture the characteristics of the exhaust plume near the discharge outlet area. Changes in the CO2 concentration were used to determine whether exhaust was accurately collected at the sampling points. The relationship between the dilution rate and distance was calculated on the basis of on-road test results using the following equation: DR = 21.4X1.16. This equation can be used for modeling purposes, especially in comparisons of model results and observations and in the evaluation of dispersion models.