A bottom-up inventory of atmospheric emissions of industrial MNVOCs in Yangtze River Delta (YRD) region was established for the period of 2010–2012. Results indicated that the total emissions of industrial VOCs increased from 3.34 Tg in 2010 to 3.99 Tg in 2012 at an annual average rate of 9.3%. Furniture manufacturing, machinery equipment manufacturing, architectural ornament, and petroleum refining were estimated to be the key sources, which contributed 58.6% of the total emissions in 2012. Based on the population database, the emission inventory was gridded into 1 km × 1 km grid cells with ArcGIS, which indicated that VOC emissions exhibited remarkable spatial and temporal characteristics. The most polluted areas were mainly centered in Shanghai, Nanjing, Ningbo, Hefei, and the Hangzhou and Taihu lake basin, which were the most developed and industrialized regions in the YRD. VOC emissions from specified anthropogenic sources under three different control scenarios for the different emission targets in 2030 were projected. The estimated average removal efficiency of the control technologies for each anthropogenic source should improve by 68.1% (scenario 2030B) and 79.0% (scenario 2030C). An entire process-control management scheme needs to be established based on the investigation of industrial processes, and the proportion of the application should be improved in the future.