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Indoor Aeroallergens in Asthmatic Pediatric Population in Annaba (Algeria)

Category: Air Pollution and Health Effects

Volume: 17 | Issue: 10 | Pages: 2482-2490
DOI: 10.4209/aaqr.2016.06.0222
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Sihem Meharzi1,2, Rokia Mansouri3, Narimène Chekchaki1,2, Nadira Bouchair4, Aïda Belgharssa4, Arlette Tridon5, Mahfoud Messarah 1, Amel Boumendjel1

  • 1 Laboratory of Biochemistry and Environmental Toxicology, Badji Mokhtar University, Annaba, Algeria
  • 2 Laboratory of Applied Biochemistry and Microbiology, Badji Mokhtar University, Annaba, Algeria
  • 3 Laboratory of Parasitology, CHU Ibn Sina, Annaba, Algeria
  • 4 Polyclinic of Pediatrics, CHU Sainte Thérèse, Annaba, Algeria
  • 5 Laboratory of Immunology, Faculties of Medicine and Pharmacy, Clermont Ferrand, France

Highlights

Indoor temperature & humidity were favorable for mold growth& mites’ development.
All homes of asthmatic children contain fungal spores (indoor air & dust samples).
Highly significant correlation Penicillium vs. environmental indoor temperature.
Association Cladosporium and Alternaria vs. sensitization to fungi.
The strongest sensitization was found with dust mites.


Abstract

The aim of the present study is to highlight the kind of indoor aeroallergens and assess their role in asthma severity in children from Annaba city (Algeria). Our study concerned 68 asthmatic children and 50 healthy children. All children's blood samples were obtained to determine biological parameters, followed by home visit to these children to assess meteorological parameters and fungal exposure. It was found that the asthma severity was associated with eosinophilia (χ2, p = 0.01), rate of total IgE (χ2, p < 0.001) and sensitization to indoor aeroallergens. This association between the severity of the disease and sensitization was strengthened with the presence of mites (χ2, p < 0.01) and pets, namely cats (p < 0.001). Moreover, all houses of asthmatic children contain fungal spores, which were also associated with the sensitization to fungi (χ2, p < 0.001). The average indoor temperature and humidity in the houses of asthmatic children represent favorable conditions for the growth of mold and development of mites, whose presence, especially Cladosporium and Alternaria, was associated with sensitization to fungi and severity of asthma. The strongest sensitization was found with dust mites (Dermatophagoides pteronyssinus, Der p1 (d1) and Dermatophagoides farinae, Der f2 (d2)) which is closely associated with asthma severity.

Keywords

Annaba (Algeria) Asthma Indoor aeroallergens Children Sensitization


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