Measurements on size distribution of atmospheric aerosol were made at Anantapur, during January to December 2005. A ten channel Quartz Crystal Microbalance Cascade Impactor (QCM) is used to study the response of aerosol characteristics to mesoscale and synoptic processes. The accumulation mode aerosol mass concentration (submicron Ma ≈ 0.4 to 0.05 μm) is found to be minimum (~10 μg/m3) and maximum (~27 μg/m3) during the months March–August and November–December, 2005 respectively. Coarse mode aerosol mass concentration (supermicron Mc ≈ 12.5 to 0.8 μm) is found to be maximum (~17 μg/m3) during the months of July and September 2005. The effect of wind on the concentration of Mc and Ma has been studied. The variation in the effective radius (Reff) from 0.1 μm to 0.4 μm indicates how the size of the particles varied seasonally. The present study brings out the fact that the size distributions on aerosols are very much affected by the meteorological parameters.